教授：陳新
Email:xinchen@cczu.edu.cn
教育經(jīng)歷:
1993, Ph.D. (Major: synthetic organic chemistry), Lanzhou University, China.
(博士，蘭州大學化學系) Advisor: Yulin Li
1990, M.Sc. (Major: organic chemistry), Lanzhou University, China.
(碩士，蘭州大學化學系)Advisor: Ziyi Zhang
1987, B.Sc. (Major: organic chemistry), Lanzhou University, China.
(學士，蘭州大學化學系)
工作經(jīng)歷：
2010-present Professor of Chemistry
School of Pharmacy, Changzhou University, China.
(常州大學, 教授)
2004-2010 Director of Small Molecule Synthesis Facility & Assistant Research Professor
Department of Chemistry, Duke University, North Carolina, USA.
(美國杜克大學化學系, 研究助教授，小分子合成中心主任)
2001-2003 Senior Research Scientist
TransTech Pharma Inc., North Carolina, USA.
(美國TransTech Pharma制藥公司, 資深科學家)
2000-2001 Postdoctoral Research Associate
Department of Chemistry, Duke University, North Carolina, USA
(美國杜克大學化學系, 博士后)
1997-1999 Postdoctoral Fellow
Department of Entomology, University of California, Riverside, California, USA
(美國加州大學河濱分校昆蟲學系, 博士后)
1995-1997 Associate Professor
Department of Chemistry, Tsinghua University, Beijing, China
(清華大學化學系, 副教授)
1993-1995 Postdoctoral Researcher
Department of Chemistry, Tsinghua University, Beijing, China
(清華大學化學系, 博士后)
個人榮譽：
1、The fourth national rural innovation and entrepreneurship and project creative competition finals (second prize), 2020
(第四屆全國農(nóng)村創(chuàng)新創(chuàng)業(yè)項目創(chuàng)意大賽總決賽二等獎, 2020)
2、Science and technology progress prize (third prize), CPCIF (China’s Petroleum and Chemical Industry Federation), 2019
(中國石油和化學工業(yè)聯(lián)合會科技進步獎三等獎, 2019)
3、International Technology Cooperation Certificate of Award, CPCIF (China’s Petroleum and Chemical Industry Federation), 2017
(中國石油和化學工業(yè)聯(lián)合會國際科技合作獎, 2017)
4、Science and technology progress prize (first prize), Changzhou City Government, China (2015)
(常州市科技進步獎一等獎, 2015)
5、Outstanding Researcher of Jiangsu Province (2014)
(第11屆江蘇省優(yōu)秀科技工作者, 2014)
6、Top-Ten Excellent Researchers of Changzhou City (2014)
(常州市十佳科技工作者, 2014)
7、Team award of excellent advisor for undergraduate thesis of Jiangsu Province (2012, 2017)
(江蘇省高校本?？苾?yōu)秀畢業(yè)設計(論文) 優(yōu)秀畢業(yè)設計團隊獎, 2012年度，2017年度)
8、Second-level talented scientist of “333 High-level Talent Training Program” of Jiangsu Province
(江蘇省“333高層次人才培養(yǎng)工程” 第二層次培養(yǎng)對象) (2011-2015)
9、Innovative and entrepreneurial talent of Jiangsu Province (2010)
(江蘇省“雙創(chuàng)人才”)
研究方向:
1. Small-molecule allosteric modulators for β- adrenergic receptor
(β-腎上腺素受體的小分子別構(gòu)調(diào)節(jié)劑研究)
2. Drug discovery for treating infection and tumors;
(新型抗生素和抗癌藥物研究)
3. Synthesis of small molecules with important biological activities.(具有重要生物活性有機小分子的合成方法研究)
基金課題：
1. National Science Foundation of China project (grant No. 22077012): “Study on novel small-molecule negative allosteric modulators for the β2-adrenergic receptor” (2021-2024, PI)
國家自然科學基金面上項目(代號22077012):“β2-腎上腺素受體的新型小分子別構(gòu)拮抗劑研究” (2021-2024，63萬元，主持)。
2. Jiangsu Provincial Agricultural Shan-Xin Program project (grant No. SXGC[2016]070): “Integrated innovation and application of green control technology of pear and peach pests” (2016-2017, PI).
江蘇省農(nóng)業(yè)三新工程項目(代號SXGC[2016]070): “桃梨害蟲綠色防控技術(shù)的集成創(chuàng)新及應用示范 ” (2016-2017，30萬元，主持)。
3. National Science Foundation of China project (grant No. 21272029): “Study on novel inhibitors of type III secretion system for Pseudomonas aeruginosa” (2013-2016, PI)
國家自然科學基金面上項目(代號21272029): “綠膿桿菌III型分泌系統(tǒng)的新抑制劑研究” (2013-2016，80萬元，主持)。
4. National Science Foundation of China project (grant No. 81272982): “Structure-activity relationship study of Garcinol for oral cancer chemoprevention” (2013-2016, Co-PI)
國家自然科學基金面上項目(代號81272982): “山竹醇在口腔癌化學預防中的構(gòu)效關系研究” (2013-2016，50萬元，合作主持)。
5. Technology Supporting Program of Jiangsu Province project: “Efficient sex pheromone technology and its application for pollution-controlling management of vegetable pests” (2012-2014, PI)
江蘇省科技支撐計劃項目: “無公害防治蔬菜害蟲的高效生物信息素技術(shù)及應用開發(fā)”(2012-2014，40萬元，主持)
學術(shù)論文：
Shuai Zhao, Xiang-Xiang Chen, Nan Gao, Ming-Cheng Qian, Xin Chen*. Visible-Light-Mediated Cyclopropanation Reaction of 3-diazooxindoles with Arenes. J. Org. Chem. 2021, 86: 7131-7140.
2. Mingcheng Qian, Xinyu Jiang, Mingting Zhang, Lijuan Hu, Huimin Liu, Shuai Zhao, Xiaoying Zhou*, Xin Chen*. Synthesis, biological evaluation, and docking study of ring-opening amide analogues of matrine as anti-tumor agents. Chem. Biodiversity, 2021, 18: e2000979.
3. Qi Liu, Qing-Tao He, Xiaoxuan Lyu, Fan Yang, Zhong-Liang Zhu, Peng Xiao, Zhao Yang, Feng Zhang, Zhao-Ya Yang, Xiao-Yan Wang, Peng Sun, Qian-Wen Wang, Chang-Xin Qu, Zheng Gong, Jing-Yu Lin, Zhen Xu, Shao-Le Song, Shen-Ming Huang, Sheng-Chao Guo, Ming-Jie Han, Kong-Kai Zhu, Xin Chen, Alem W. Kahsai, Kun-Hong Xiao, Wei Kong, Fa-Hui Li, Ke Ruan, Zi-Jian Li, Xiao Yu, Xiao-Gang Niu, Chang-Wen Jin, Jiangyun Wang*, Jing-Peng Sun*. DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. Nature Communications, 2020, 11: 4857.
4. Shuai Zhao, Shengchao Guo, Chan Yang, Zheng Gong, Yaomin Wang, Yingli Jia, Xinyu Jiang, Liwei Xu, Li Shi, Xiao Yu, Jinpeng Sun*, Yan Zhang*, Xin Chen*. Cell active and functionally-relevant small-molecule agonists of calcitonin receptor. Bioorg. Chem. 2020, 96, 103596.
5. Anthony H. Nguyen, Alex R. B. Thomsen, Thomas J. III Cahill, Rick Huang, Li-Yin Huang, Tara Marcink, Oliver B. Clarke, Soren Heissel, Ali Masoudi, Danya Ben-Hail, Fadi Samaan, Venkata P. Dandey, Yong Zi Tan, Chuan Hong, Jacob P. Mahoney, Sarah Triest, John Little, Xin Chen, Roger Sunahara, Jan Steyaert, Henrik Molina, Zhiheng Yu, Amedee des Georges*, Robert J. Lefkowitz*. Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex. Nature Structural & Molecular Biology, 2019, 26, 1123-1131.
6. Shuai Zhao, Lei Jin, Zhi-Li Chen, Xue Rui, Jia-Yi He, Ran Xia, Ke Chen, Xiang-Xiang Chen, Zi-Jian Yin, Xin Chen*.Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis. RSC Advances, 2019, 9, 11585-11588.
7. Shuai Zhao, Zhi-Li Chen, Xue Rui, Ming-Mei Gao, Xin Chen*. Asymmetric allylic amination of Morita-Baylis-Hillman adducts with simple aromatic amines by nucleophilic amine catalysis. Synlett, 2019, 30, 703-708.
8. Lei Jin, Shuai Zhao,Xin Chen*. Synthesis of both enantiomers of chiral phenylalanine derivatives catalyzed by cinchona alkaloid quaternary ammonium salts as asymmetric phase transfer catalysts. Molecules, 2018, 23, 1421.
9. Kaicheng Meng, Paul Shim, Qingtin Wang, Shuai Zhao, Ting Gu, Alem W. Kahsai, Seungkirl Ahn, Xin Chen*. Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β2-adrenergic receptor. Bioorg. Med. Chem. 2018, 26, 2320-2330.
10. Xiangyu Liu, Seungkirl Ahn, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, Ali Masoudi, William I. Weis, Ron O. Dror, Xin Chen, Robert J. Lefkowtiz*, Brian K. Kobilka*. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature, 2017, 548, 480-484.
11. Seungkirl Ahn, Alem W. Kahsai, Biswaranjan Pani, Qin-Ting Wang, Shuai Zhao, Alissa L. Wall, Ryan T. Strachan, Dean P. Staus, Laura M. Wingler, Lillian D. Sun, Justine Sinnaeve, Ted Cho, Gwenn M. Hansen, Michael B. Burnett, Jane Lamerdin, Daniel Bassoni, Bryant Gavino, Gitte Husemoen, Eva K. Olsen, Thomas Franch, Stefano Costanzi, Xin Chen*, Robert J. Lefkowitz*. An allosteric “Beta-Blocker” discovered from a DNA-encoded small molecule libraries. Proc. Natl. Acad. Sci. USA, 2017, 114(7), 1708-1713.
12. Thomas J. Cahill III, Alex R. B. Thomsen, Jeffrey T. Tarrasch, Bianca Plouffe, Anthony H. Nguyen, Fan Yang, Li-Yin Huang, Alem W. Kahsai, Daniel L. Bassoni, Bryant Gavino, Jane Lamerdin, Sarah Triest, Arun K. Shukla, Benjamin Berger, John Little IV, Albert Antar, Adi Blanc, Chang-Xiu Qu, Xin Chen, Kouki Kawakami, Asuka Inoue, Junken Aoki, Jan Steyaert, Jin-Peng Sun, Michel Bouvier, Georgios Skiniotis, Robert J. Lefkowitz*. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling and endocytosis. Proc. Natl. Acad. Sci. USA, 2017, 114(10), 2562-2567.
13. Xin-Ying Zhou, Jing Cao, Chao-Ming Han, Shu-Wen Li, Chen Zhang, Yin-Duan Du, Qian-Qian Zhou, Xin-Yan Zhang*, Xin Chen*.The C8 side chain is one of the key functional group of garcinol for its anti-cancer effects. Bioorg. Chem. 2017, 71, 74-80.
14. Punita Kumari, Ashish Srivastava, Ramanuj Banerjee, Eshan Ghosh, Pragya Gupta, Ravi Ranjan, Xin Chen, Bhagyashri Gupta, Charu Gupta, Deepika Jaiman, Arun K. Shukla*. Functional competence of a partially engaged GPCR-β-arrestin complex. Nature Communications, 2016, 7, 13416.
15. Lingling Gu, Shanshan Zhou, Lanping Zhu, Cuirong Liang, Xin Chen*. Small-molecule inhibitors of the type III secretion system. Molecules, 2015, 20, 17659-17674.
16. Chao-Ming Han, Xin-Ying Zhou, Jing Cao, Xin-Yan Zhang*, Xin Chen*. 13,14-Dihydroxy groups are critical for the anti-cancer effects of garcinol. Bioorg. Chem. 2015, 60, 123-129.
17. Yan Li, William Hutchins, Xiaogang Wu, Cuirong Liang, Chengfang Zhang, Xiaochen Yuan, Devanshi Khokhani, Xin Chen, Yizhou Che, Qi Wang*, Ching-Hong Yang*. Derivatives of plant phenolic compound inhibits the type III secretion system of Dickeya dadantii via HrpX/HrpY two-component signal transduction and Rsm system. Molecular Plant Pathology, 2015, 16(2), 150-163.
18. Arun K. Shukla, Gerwin H. Westfield, Kunhong Xiao, Rosana I. Reis, Li-Yin Huang, Prachi Tripathi-Shukla, Jiang Qian, Sheng Li, Adi Blanc, Austin N. Oleskie, Anne M. Dosey, Min Su, Cui-Rong Liang, Ling-Ling Gu, Jin-Ming Shan, Xin Chen, Rachel Hanna, Minjung Choi, Xiao Jie Yao, Bjoern U. Klink, Alem W. Kahsai, Sachdev S. Sidhu, Pawel A. Penczek, Shohei Koide, Anthony A. Kossiakoff, Virgil L. Woods Jr., Brian K. Kobilka*, Georgios Skiniotis*, Robert J. Lefkowitz*. Visualization of arrestin recruitment by a G protein-coupled receptor. Nature, 2014, 512, 218-222.
19. Yu-Hui Luo, Feng-Xia Yue, Xiao-Yang Yu, Xin Chen*, Hong Zhang*. Coordination polymers of lanthanide complexes with benzene dicarboxylato ligands. CrystEngComm, 2013, 15, 6340-6348.
20. Yu-Hui Luo, Feng-Xia Yue, Xiao-Yang Yu, Ling-Ling Gu, Hong Zhang*, Xin Chen*. A series of entangled ZnII/CdII coordination polymers constructed from 1,3,5-benzenetricarboxylate acid and flexible triazole ligands. CrystEngComm, 2013, 15, 8116-8124.
21. Zheng-Yi Li, Hong-Zhao Ma, Chen Han, Hai-Tao Xi, Qi Meng, Xin Chen*, Xiao-Qiang Sun*. Synthesis of isothiocyanates by reaction of amines with phenyl chlorothionoformate via one-pot or two-step process. Synthesis, 2013, 45, 1667-1674.
22. Devanshi Khokhani, Chengfang Zhang, Yan Li, Qi Wang, Quan Zeng, Akihiro Yamazaki, William Hutchins, Shan-Shan Zhou, Xin Chen*, Ching-Hong Yang*. Discovery of plant phenolic compounds that act as type three secretion system inhibitors or inducers of fire blight pathogen Erwinia amylovora. Applied and Environmental Microbiology, 2013, 79, 5424-5436.
23. Kun Hu，Yan-Jie Qi，Juan Zhao，He-Fei Jiang，Xin Chen*，Jie Ren*. Synthesis and biological evaluation of novel sulforaphane derivatives as potential antitumor agents. Eur. J. Med. Chem. 2013, 64, 529-539
24. Xin Chen,Xinyan Zhang, Ye Lu, Joong-Youn Shim, Shengmin Sang, Zheng Sun*, Xiaoxin Chen*. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Hamster Cheek Pouch Carcinogenesis by a 5-Lipoxygenase Inhibitor, Garcinol. Nutrition & Cancer 2012, 64, 1211-1218.
25. Jie Ren, Hua-Jin Xu, Hong Cheng, Wen-Qun Xin，Xin Chen*, Kun Hu*. Synthesis and antitumor activity of Formononetin nitrogen mustard derivatives. Eur. J. Med. Chem. 2012, 54, 175-187.
26. Kun Hu, Lin Wu, Wen-Qun Xin, Xin Chen*, Jie Ren*. Synthesis and biological evaluation of anticancer activity for novel 4β-amino oxadiazole derivatives of podophyllotoxin. Bioorg. Med. Chem. Lett. 2012, 22, 4778-4782.
27. Akihiro Yamazaki, Jin Li, Quan Zeng, Devanshi Khokhani, William C. Hutchins, Angela C. Yost, Eulandria Biddle, Eric J. Toone, Xin Chen*, Ching-Hong Yang*. Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS/GacA two component signal transduction system. Antimicrob. Agents Chemother. 2012, 56, 36-43.
28. Xin Chen*, Zhengyi Li, Xiaoqiang Sun, Hongzhao Ma, Xiaoxin Chen, Jie Ren, Kun Hu. New method for synthesis of sulforaphane and the related isothiocyanates. Synthesis, 2011, 3991-3996.
29. Bidong D. Nguyen, Doreen F. Cunningham, Xiaofei Liang, Xin Chen, Eric J. Toone, Christian R. H. Raetz, Pei Zhou, Raphael H. Valdivia*. Lipooligosaccharide is required for the developmental transition of replicative Reticulate Bodies to infectious Elementary Bodies in Chlamydia trachomatis.Proc. Natl. Acad. Sci. USA, 2011, 108, 10284-10289.
30. Warren S. Warren*, Elizabeth Jenista, Rosa Tamara Branca, Xin Chen. Increasing hyperpolarized spin lifetimes through true singlet eigenstates. Science, 2009, 323, 1711-1714.
