楊海濤（教授）
Email : yanght@cczu.edu.cn
教育經(jīng)歷:
2001年9月～ 2006年12月：中國科學(xué)技術(shù)大學(xué)化學(xué)系有機化學(xué)專業(yè)(碩、博)
1996年9月～ 2000年7月：安徽大學(xué)化學(xué)系應(yīng)用化學(xué)專業(yè)
工作經(jīng)歷：
2006.12-至今：常州大學(xué)石油化工學(xué)院
2011.3～2011.8，加拿大國家研究院生物科學(xué)研究所（NRC-IBS），訪問學(xué)者
研究方向:
1. 圍繞“新方法、新結(jié)構(gòu)、新反應(yīng)”開展有機合成方法學(xué)的研究，主要研究基于肟類化合物實現(xiàn)各類含氮雜環(huán)的高效構(gòu)建
2. 藥物合成工藝開發(fā)及改進
科研項目:
1. 2022.5-2023.6，酒石酸伐尼克蘭的合成工藝開發(fā)，常州四藥制藥有限公司，主要負責(zé)人
2. 2019.12-2020.12，MCC和MBQ的合成技術(shù)路線和工藝開發(fā)，常州四藥制藥有限公司，主要負責(zé)人
3. 2019.11-2020.03，雙縮酮制備醋酸烏立妥環(huán)氧物，常州四藥制藥有限公司，主要負責(zé)人
4. 2014.12-2016.12，碘試劑作用下富勒烯衍生化新方法研究，江蘇省自然科學(xué)基金面上項目，項目負責(zé)人
5. 2009.12-2012.12，富勒烯參與的自由基新反應(yīng)研究，國家自然科學(xué)基金（青年），項目負責(zé)人
發(fā)表論文：
1. Hai-Tao Yang,* Su-Qing Zhou, Dan-Mei Chen, Zi-Jun Hu, Xiao-Qi Qiang, Xiao-Qing Song, Sheng Tan, Wei-Hua Jiang, Yong-Qiang Sun, Chun-Bao Miao,* “Copper-Catalyzed Annulation of O?Acyl Oximes with Cyclic 1,3-Diones for the Synthesis of 7,8-Dihydroindolizin-5(6H)?ones and Cyclohexanone-Fused Furans”, Org. Lett.2023, 25, 838-842.
2. Chun-Bao Miao,* Xiao-Qi Qiang, Xiaoli Xu, Xiao-Qing Song, Su-Qing Zhou, Xinyu Lyu, Hai-Tao Yang,* “Synthesis of Stable N-H Imines with a Benzo[7,8]indolizine Core and Benzo[7,8]indolizino[1,2-c]quinolines via Copper-Catalyzed Annulation of α,β-Unsaturated O-Acyl Ketoximes with Isoquinolinium N-Ylides”, Org. Lett.2022, 24, 3828-3833.
3. Chun-Bao Miao,* Hong-Rong Guan, YiHan Tang, Kun Wang, Wen-Long Ren, Xinyu Lyu, Changsheng Yao, Hai-Tao Yang,* “Copper-Catalyzed Bisannulations of Malonate-Tethered O?Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues”, Org. Lett.2021, 23, 8699-8704.
4. Kun Wang, Hong-Rong Guan, Wen-Long Ren, Hai-Tao Yang,* Chun-Bao Miao,* “Copper-Catalyzed Cascade Annulation of Malonate-Tethered O?Acyl Oximes with Cyclic 1,3-Dicarbonyl Compounds for the Synthesis of Spiro-Pentacyclic Derivatives”, J. Org. Chem. 2021, 86, 12309-12317.
5. Li-Jin Zhou, Kun Wang, Hong-Rong Guan, An-Qi Zheng, Hai-Tao Yang,* and Chun-Bao Miao,* “Cu(OAc)2?Promoted Oxidative Cross-Dehydrogenative Coupling Reaction of α?Acylmethyl Malonates with Indole Derivatives to Access 3?Functionalized Indoles and Polycyclic Indoles”, J. Org. Chem. 2020, 85, 7925-7938.
6. Chun-Bao Miao,* An-Qi Zheng, Li-Jin Zhou, Xinyu Lyu, and Hai-Tao Yang,* “Copper-Catalyzed Annulation of Oxime Acetates with α?Amino Acid Ester Derivatives: Synthesis of 3?Sulfonamido/Imino 4?Pyrrolin-2-ones”, Org. Lett.2020, 22, 3381-3385.
7. Peng-Fei Mao, Li-Jin Zhou, An-Qi Zheng, Chun-Bao Miao,* Hai-Tao Yang,* “Cu(OAc)2?Triggered Cascade Reaction of Malonate-Tethered Acyl Oximes with Indoles, Indole-2-alcohols, and Indole-2-carboxamides”, Org. Lett.2019, 21, 5882-5885.
8. Yong-Jian Liu, Jie Ge, Chun-Bao Miao, Hai-Tao Yang,* “Copper-Catalyzed Reaction of C60 with Tertiary Amines for the Preparation of Spiro-Linked Methanofullerenes and Fullerenoalkanals”, J. Org. Chem. 2019, 84, 6134-6142.
9. Qiaoqiao Teng, Yi-Chen Tan, Chun-Bao Miao, Xiao-Qiang Sun, Hai-Tao Yang,* “Tunable Copper-Catalyzed Reaction of C60 with 2-Ethoxycarbonylacetamides and Subsequent BF3?Et2O-Mediated Isomerization of the Generated Dihydrofuran-Fused Fullerenes to Fulleropyrrolidinones”,J. Org. Chem. 2018, 83, 15268-15276.
10. He Wu, Yan-Fang Sun, Chen Zhang, Chun-Bao Miao, Hai-Tao Yang,* “A facile method for the preparation of carbodiimides from thioureas and (Boc)2O”, Tetrahedro Lett.2018, 59, 739-742.
11. Hai-Tao Yang,* Jie Ge, Xin-Wei Lu, Xiao-Qiang Sun, Chun-Bao Miao, “Copper-Catalyzed Functionalizations of C60 with Amino Alcohols”, J. Org. Chem.2017, 82, 5873-5880.
12. Qi Meng,* Jun-Yu Chen, Chun-Bao Miao, Xiao-Qiang Sun, Hai-Tao Yang,* “Lewis base-catalyzed double nucleophilic substitution reaction of N-tosylaziridinofullerene with thioureas or guanidines”, Tetrahedron Lett.2017, 58, 2566-2570.
13. Hai-Tao Yang,* Yi-Chen Tan, Jie Ge, He Wu, Jia-Xing Li,* Yang Yang, Xiao-Qiang Sun, Chun-Bao Miao,* “Reaction of C60 with Inactive Secondary Amines and Aldehydes and the Cu(OAc)2?Promoted Regioselective Intramolecular C?H Functionalization of the Generated Fulleropyrrolidines”, J. Org. Chem.2016, 81, 11201-11209.
14. Hai-Tao Yang,* Yi-Chen Tan, Yang Yang, Xiao-Qiang Sun, Chun-Bao Miao, “Cu(OAc)2-Mediated Reaction of C60 with Ureas for the Preparation of Fulleroimidazolidinones”, J. Org. Chem.2016, 81, 1157-1163.
15. Xin-Wei Lu, Meng-Lei Xing, Chun-Bao Miao, Jia-Xing Li, Xiao-Qiang Sun,* Hai-Tao Yang,* “Cu(OAc)2-promoted reaction of [60]fullerene with primary amines or diamines”, Org. Biomol. Chem.2015, 13, 8405-8410.
16. Hai-Tao Yang,* Xin-Wei Lu, Meng-Lei Xing, Xiao-Qiang Sun, Chun-Bao Miao,*“Hypervalent Iodine Reagent Mediated Diamination of [60]Fullerene with Sulfamides or Phosphoryl Diamides”, Org. Lett.2014, 16, 5882-5885.
17. Meng-Lei Xing, Xin-Wei Lu, Chun-Bao Miao, Jia-Xing Li, Xiao-Qiang Sun, Hai-Tao Yang,* “Lewis Base-Catalyzed Reaction of Aziridinofullerene with Ureas for the Preparation of Fulleroimidazolidinones”, J. Org. Chem.2014, 79, 11774-11779.
18. Hai-Tao Yang,* Meng-Lei Xing, Xin-Wei Lu, Jia-Xing Li, Jiang Cheng, Xiao-Qiang Sun, Chun-Bao Miao, “BF3·Et2O- or DMAP-Catalyzed Double Nucleophilic Substitution Reaction of Aziridinofullerenes with Sulfamides or Amidines”, J. Org. Chem.2014, 79, 11744-11749.
19. Hai-Tao Yang,* Meng-Lei Xing, Ye-Fei Zhu, Xiao-Qiang Sun, Jiang Cheng, Chun-Bao Miao, Fa-Bao Li,* “BF3×Et2O-Catalyzed Formal [3+2] Reaction of Aziridinofullerenes with Carbonyl Compounds”, J. Org. Chem.2014, 79, 1487-1492.
20. Chun-Bao Miao,* Xin-Wei Lu, Ping Wu, Jiaxing Li, Wen-Long Ren, Meng-Lei xing, Xiao-Qiang Sun, Hai-Tao Yang,* “Hypervalent Iodine Reagent-Mediated Reaction of [60]Fullerene with Amines”, J. Org. Chem.2013, 78, 12257-12262.
21. Hai-Tao Yang,* Xi-Chen Liang, Yan-Hong Wang, Yang Yang, Xiao-Qiang Sun,* Chun-Bao Miao, “CuCl2-Mediated the Reaction of [60]Fullerene with Amines in the Presence or Absence of Dimethyl Acetylenedicarboxylate: Preparation of Fulleropyrroline or Aziridinofullerene Derivatives”, J. Org. Chem.2013, 78, 11992-11998.
22. Hai-Tao Yang,* Wen-Long Ren, Chun-Ping Dong, Yang Yang, Xiao-Qiang Sun, Chun-Bao Miao,* “PhI(OAc)2/I2-mediated [3+2] reaction of [60]fullerene with amides for the preparation of fullerooxazoles”, Tetrahedron Lett.2013, 54, 6799-6803.
23. Hai-Tao Yang,* Xi-Chen Liang, Yan-Hong Wang, Yang Yang, Xiao-Qiang Sun,* Chun-Bao Miao, “CuI-Catalyzed Oxidative [3+2] Reaction of Fullerene with Amidines or Amides Using Air as the Oxidant: Preparation of Fulleroimidazole or Fullerooxazole Derivatives”, Org. Lett.2013, 15, 4650-4653.
24. Hai-Tao Yang,* Wen-Long Ren, Chun-Bao Miao, Chun-Ping Dong, Yang Yang, Hai-Tao Xi, Qi Meng, Yan Jiang, Xiao-Qiang Sun,* “DMAP-Catalyzed [3+2] and [4+2] Cycloaddition Reactions between [60]fullerene and Unmodified Morita–Baylis–Hillman Adducts in the Presence of Ac2O”, J. Org. Chem.2013, 78, 1163-1170.
25. Hai-Tao Yang,* Wen-Long Ren, Xiao-Jiao Ruan, Zong-Yong Tian, Xi-Chen Liang, Chen Han, Xiao-Qiang Sun,* Chun-Bao Miao, “Reaction of [60]fullerene with α-alkoxyl/acyloxyl/phenolyl ketoxime: unusual C-C and C-O bond cleavage”, Tetrahedron Lett.2013, 54, 1428-1431.
26. Hai-Tao Yang,* Zong-Yong Tian, Xiao-Jiao Ruan, Min Zhang, Chun-Bao Miao, Xiao-Qiang Sun,* “CuBr/PMDETA-Mediated Reactions of [60]Fullerene with Active Halides: Preparation of Methano[60]fullerene Derivatives”, Eur. J. Org. Chem.2012, 4918-4922.
27. Chun-Bao Miao,* Min Zhang, Zong-Yong Tian, Hai-Tao Xi, Xiao-Qiang Sun, Hai-Tao Yang,*“Base-Controlled Selective Conversion of Michael Adducts of Malonates with Enones in the Presence of Iodine”, J. Org. Chem.2011, 76, 9809-9816.
